Endocrine Abstracts

Introduction: Alzheimer’s Disease (AD) is a multifactorial disease. The hypothalamo-pituitary–adrenal (HPA)-axis shows extensive changes in AD. It is observed a hyperactivation of corticotropin-releasing hormone (CRH) neurons with age, which is significantly present in men. The aim of this study is to compare serum levels of cortisol in patients with Alzheimer’s disease and normal controls.Material and Methods: Ninety patients with AD and ...

Introduction: Acromegaly is a systematic disease with charecteristic clinical features, which is due to GH hypersecretion mainly from pituitary adenomas and in rare cases it can be due to ectopic GHRH and GH hypersecretion. Sometimes localizing the source of hypersecretion is difficult. Here we present a case of a woman with acromegalic phenotype and empty sella.Presentation: A 47 years old woman referred to our department after recent onset of high bloo...

Introduction: Leptin receptors have been identified in many peripheral tissues as well as the CNS including the hippocampus, which is particularly vulnerable in Alzheimer’s disease (AD). Animal data shows that leptin may be implicated in the pathophysiology of AD. The aim of this study was to examine if there is any differences in serum leptin levels between patients with AD and normal controls.Material and methods: Ninety patients with AD and 95 no...

Introduction: There is a great interest in the association of thyroid hormones and mood. Although it appears to be important interactions between the central regulation of mood and the thyroid axis, the effects of antidepressants and especially of selective serotonin reuptake inhibitors (SSRIs) remain ambiguous. We investigated the thyroid function in perimenopausal women suffering from depression.Material and methods: We examined 102 perimenopausal wome...

Introduction: Hot flashes and night sweating are the most common medical complaints in women during the menopausal transition and they are strongly associated with the presence of perimenopausal depression. The pathophysiology of hot flashes has not been elucidated. Peripheral vasodilation and increase in skin temperature observed in women with hot flashes might be induced by changes in brain neurotransmitters and instability in the hypothalamic thermoregulatory center due to ...

Introduction: Several studies have investigated determinants for androgen levels in men, but few studies have included women. Epidemiological evidence has suggested that cigarette smoking has an anti-oestrogenic effect in women, but the effects of smoking on steroid hormone metabolism are not fully understood. We investigated whether there is a relationship between androgen levels and smoking in perimenopausal women.Material and methods: We examined 75 p...

Background: Although IV steroids are the treatment of choice for moderate-to-severe graves orbitopathy (M-S GO), the most efficacious regimen is not yet defined. Cases not responding or relapsing after steroid treatment (STx) are not uncommon and STx can cause serious adverse events. The aim of the present study is to define the steroid regimen which balances between efficacy and damage, using stir-sequence orbital-MRI (SsMRIo) as an additional objective tool for the evaluatio...